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14-3-3 proteins in the nervous system

Identifieur interne : 001810 ( Main/Exploration ); précédent : 001809; suivant : 001811

14-3-3 proteins in the nervous system

Auteurs : Daniela Berg [Allemagne] ; Carsten Holzmann [Allemagne] ; Olaf Riess [Allemagne]

Source :

RBID : ISTEX:BCFB7F34724CB68FADF584F02B6E0EB0C093045D

Abstract

14-3-3 proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. Although the function of this family of highly conserved proteins is not completely known, recent evidence indicates their involvement in multiple cellular processes. By their interaction with more than 100 binding partners, 14-3-3 proteins modulate the action of proteins that are involved in cell cycle and transcriptional control, signal transduction, intracellular trafficking and regulation of ion channels. The study of some of these interactions is sheding light on the role of 14-3-3 proteins in processes such as apoptosis and neurodegeneration.

Url:
DOI: 10.1038/nrn1197


Affiliations:


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